The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole.
نویسندگان
چکیده
The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 2 شماره
صفحات -
تاریخ انتشار 2015